Hello, this is Haro from Yak Al..

I'm sure you've all thought about wanting the six-pack abs of idols or actors you see on TV.?

At least I have..

To achieve that, you need not only exercise and diet, but also,

I think using appropriate supplements is important..

However, just because you want to lose a lot of weight and reduce body fat,,

taking supplements excessively can cause serious problems for your body..

‘The Chinese idiom 'excess is as bad as deficiency' (éç¶ä¸å)

is a term I believe is especially valued in the world of medicine..

Last time, we looked at what benefits garcinia extract has for dieting,

and how to use it properly..

This time, I'm going to explain why garcinia extract fits the meaning of 'excess is as bad as deficiency',

and inform you about the dangers of garcinia extract..

Is there a reason why you shouldn't take more garcinia extract than the recommended dose??

In a previous column, we mentioned that

HCA (hydroxy citric acid) found in garcinia extract

is effective at reducing body fat. .

Before answering the question above, let's look at how HCA works as a diet supplement.

.

Simply put, the mechanism by which carbohydrates are stored as fat is as follows:.

Carbohydrate intake â Glycolysis â TCA cycle â Acetyl CoA â Fatty acid synthesis mechanism

Among these, HCA

HCA inhibits citrate ATP lyase,

which converts citrate, an intermediate of the TCA cycle, to Acetyl CoA..

Since the explanation might be a bit complicated, let me simplify it..

“HCA prevents the conversion of citrate to Acetyl CoA, thereby preventing conversion to fat.“.

Acetyl CoA is the building block needed to synthesize fatty acids, so,

if you don't have the building block, you can't make fatty acids.?

Through this mechanism, HCA prevents the synthesis of fatty acids, and,

instead of carbohydrates being converted to fat,

they are stored as glycogen in the liver and muscles,

so the body can use them directly when energy is needed later..

This can help reduce body fat accumulation, but,

problems arise if you take too much..

Fat is a kind of energy source..

However, if you consume excessive HCA,

the synthesis of fat that would be used as an energy source decreases, and

fatigue and muscle weakness can occur..

When muscles use energy, they use glycogen,but,

the energy source responsible for sustained energy supply over the long term is fat.So if fat synthesis is suppressed and carbohydrate stores are depleted,,

to obtain needed energy, protein can be broken down and used as an energy source..

This means that as muscle protein is broken down,

muscle mass decreases and muscle weakness can occur..

What other side effects does garcinia extract have??

Side effects of garcinia extract

Gastrointestinal upset

When you take garcinia extract,

gastrointestinal problems such as heartburn, abdominal pain, nausea, and diarrhea can occur..

Risk of liver damage

With excessive intake or long-term use, liver toxicity can occur,so,

those with liver problems should be cautious about taking it..

Heart rhythm problems

Some studies report that garcinia extract may interfere with electrolyte balance and cause

heart problems such as arrhythmia or blood pressure changes..

Problems with male testes

(Source: Ministry of Food and Drug Safety)

Recently, the Ministry of Food and Drug Safety reduced the recommended daily limit

from HCA 2800mg to 1500mg, a reduction of 46%,,

because excessive intake is known to cause problems with male testes. .

*As a recent change,,

many health supplement companies are selling products without adhering to this standard, so,

you should pay special attention to this aspect..

Drug interactions and allergic reactions and other side effects

Since drug interactions are diverse,,

it's a good idea to consult with doctors or pharmacists about these matters..

Cold medicines or antidepressants,,

especially medications that promote serotonin secretionâif you're taking these

and then take garcinia,

excessive serotonin can be secreted in the nervous system, which

can cause serotonin syndrome..

As such, garcinia extract has several side effects, but,

among them, the side effects you should be most careful about are

risk of liver damage and heart rhythm problems..

Due to these side effects, the Ministry of Food and Drug Safety is concerned about

liver damage such as acute hepatitis and

heart problems such as tachycardia, and has established precautions for garcinia extract, stating that people suffering from liver or heart problems must consult with a professional before taking it.

.

3-line summary

Taking more garcinia extract than the recommended dose to see greater diet effects does more harm than good..
In particular, for those with liver or heart problems, it is recommended to consult with a professional before taking it..
Drug interactions are also important; rather than patients researching this themselves, consulting with doctors or pharmacists is better..

References

acute liver injury following garcinia cambogia weight-loss supplementation: case series and literature review, giada crescioli, internal and emergency medicine, 2018
hepatotoxicity associated with garcinia cambogia: a case report and review of the literature, jennifer L. lunsford, Journal of Medical Toxicology, 2016
Pharmaceutical Information Center "Garcinia cambogia extract”
Ministry of Food and Drug Safety "Standards and Specifications for Health Functional Foods"“