Hello, this is Gwak Cheol from PharmAlly.!

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Everything that goes into my mouth..

The path to choosing it is like mountain climbing...

Continuously searching.. comparing numerous supplements..

And searching again.. asking ChatGPT too..

But our readers.. can comfortably ride the cable car created by this Gwak Cheol.

Because this Gwak Cheol did all the hard work..

Our readers can enjoy the air and scenery at the summit!

The reason I hope you read Gwak Cheol's column rather than ChatGPT is

Gwak Cheol presents things simply and in detail, along with interesting research results as well, and I hope you enjoy it to the end...

(And above all, I'm.. cute..)

Now then, the cable car departs..

<Important! Criteria for Selecting Vitamin E Supplements>

When selecting a vitamin E supplement, the following 4 factors will be important..

1. Natural Vitamin E (D-alpha-tocopherol))

: Because the natural form of vitamin E has higher absorption than the synthetic form

You need to distinguish between synthetic and non-synthetic or natural through the supplement label..

Non-synthetic or natural is generally “d”-labeled as alpha-tocopherol,

and synthetic alpha-tocopherol is generally “dl”-labeled as dl-alpha-tocopherol..

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One of the important issues related to vitamin E supplement intake this way is

the lack of data showing that synthetic supplements are beneficial..

📢 Gwak Cheol brought a study comparing natural and synthetic tocopherols regarding anticancer effects, one of the major functions of vitamin E..

According to a study published in 2012,

synthetic alpha-tocopherol contained in vitamin E supplements showed no clear cancer prevention effects

while gamma and delta tocopherols contained in foods were found to help prevent colorectal cancer, breast cancer, and prostate cancer.2)

2. Vitamin E Content Relative to Daily Nutritional Reference Values

: Daily requirements for vitamin E are not well known,

and requirements are estimated according to intake of unsaturated fats that are susceptible to peroxidation..

According to the '2020 Korean Nutrient Intake Standards'released by the Ministry of Food and Drug Safety,

the adequate daily intake of vitamin E for adults is 12mg(18.12 IU),

and for pregnant women and nursing mothers are 12mg(18.12 IU), 15mg(22.65 IU)respectively..

While 100-1,000 IU per day does not cause toxicity it is recommended not to exceed 300 IU (approximately 200 mg))..

(The IU units commonly seen are for vitamins A, D, and E, and each has different dosages per 1 IU..

1 mg of vitamin E equals 1.5 IU..)

When you search for supplements to get vitamin E, you will most commonly find 400 IU dosage,

which is within the range that does not cause toxicity mentioned above, so it's a reasonable dose as long as you are careful about the intake method..

Related to this, the choice of dosage based on vitamin E intake methods and management purposes is introduced in another column, so please come read it.!!

🚨Beep beep🚨

To raise awareness about excessive intake among our readers, Gwak Cheol brought one research result..

In this study, based on 19 clinical trials and 135,967 subjects

a meta-analysis study was conducted on the dose-response relationship between vitamin E intake and total mortality using randomized controlled trial data,

and the results showed that when high-dose vitamin E (â¥400 IU/day) was used, total mortality increased statistically significantly.3)

However, the subjects using high doses in this study were adults with chronic diseases

and these results cannot be generalized to healthy adults..

3. Mixed Tocopherol Form

: Mixed tocopherol products containing various forms of vitamin E (alpha, beta, gamma, delta-tocopherol)

have a theory that they may have superior antioxidant effects through synergistic interactions..

However, since this is only a theory and some experimental results

it is recommended to first take natural alpha-tocopherol with proven effects,

and then take it after more sufficient research results come out later.!!

4. Checking Additional Ingredients

: In addition to vitamin E, there are also products that include other vitamins or antioxidant ingredients (e.g., vitamin C, selenium, etc.)..

However, if they are not necessary ingredients, choosing a pure vitamin E product without additional ingredients is also

a good approach..

📢A Word from Gwak Cheol, Who Fills Your Knowledge (Full!)

1) Vitamin C reduces oxidized vitamin E and makes it available for reuse..

2) Selenium has the functional information of 'necessary for protecting cells from harmful free radicals',

and products containing it together enable dual antioxidant care..

(Selenium is a trace element distributed in the liver, kidneys, heart, spleen, and other organs in the human body..)

This concludes Gwak Cheol's cable car ride..

…

Wait, there seem to be some readers who haven't reached the summit yet. For readers yearning for better scenery and air, here's Gwak Cheol's final move..

5. Other (The Final Move)

For this final move we raw material extraction origin and whether the raw material supplier is disclosed, GMP mark can be checked..

Natural alpha-tocopherol in supplements is usually extracted from soybean oil and,

if this origin is NON-GMO (non-genetically modified organism-derived)you can consume it with confidence..

Next is whether the raw material supplier is disclosed..

In Korea, many people have started avoiding 'made in china'

and as a result, it's common to see products that hide or fail to indicate their origin..

In light of this, supplements that confidently disclose their raw material suppliers or

beyond that, take pride in them can be one of the good selection criteria, I think..

This is Gwak Cheol's subjective opinion, and readers who agree may want to refer to it..

Finally, GMP whether the GMP mark is present..

Products with this mark are manufactured in facilities that comply with the 'Excellent Health Functional Food Manufacturing Standards' recognized by the MFDS,

and can be seen as one of the indicators you can trust and consume..

✔️ Conclusion

1. Distinguishing natural vs. synthetic alpha-tocopherol through labels ("d" vs. "dl")”)

2. Avoiding high-dose products because excessive vitamin E intake carries a risk of toxicity

3. Focus on alpha-tocopherol rather than mixed tocopherols

✔️ References

1) Preventive Pharmacy 10th Edition Korea Pharmacy Education Council Preventive Pharmacy Division Sinilbooks

2)CANCER PREVENTION RESEARCH:Dose Vitamin E Prevent or Promote Cancer?

Chung S. Yang; Nanjoo Suh; Ah-Ng Tony Kong

3)Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

Edgar R. Miller III, MD, PhDRoberto Pastor-Barriuso