[Yakkal's 3-Line Summary💊]

PDRN was originally used in hospitals for burn and wound treatmentand is the key ingredient of the ''salmon injection.'Recently, it has transitioned to an oral supplement and is drawing attention in the inner beauty market..
It is a DNA fragment extracted from salmon milt (the testis of male salmon)), and is a raw ingredient with over 97% similarity to human DNA, making it safe with few side effects..
If collagen filled in the missing materials for skin, then, PDRN takes an approach of signaling cells to regenerate on their own,working at the cellular level..

It must have been around 3 PM. While sitting in a chair in the dermatology clinic waiting room, I overheard a quiet conversation from the next seat..

"'They say taking PDRN supplement after getting Rejuran makes the effect last longer.'."

"'What's that? You mean taking the salmon injection orally?'?"

"'Yeah, oral salmon injection. That's what everyone's calling it these days.'."

I didn't turn my head, but my ears naturally tilted toward them. It's a component name I've heard countless times working as a pharmacist, but it's relatively recently that it's mixed into everyday conversations like this..

From the treatment room to the dinner table

PDRN PDRN first appeared in the medical field in the early 1990s. It started with PlacentexÂ®, a product developed by the Italian pharmaceutical company Mastelli. Originally, it was a specialized pharmaceutical intended to treat serious tissue damage such as burns, chronic ulcers, and musculoskeletal injuries..

Subsequently, in Korea, centered around dermatology and cosmetic surgery, skin booster injections, became widely known by the nickname 'salmon injection.' It was a procedure involving direct injection into the dermal layer for the purpose of skin regeneration and improved elasticity..

However, in recent years, the landscape surrounding this ingredient has been changing..

People who received the procedure and wanted to maintain the effects longer began seeking out supplements containing the same ingredient. In beauty communities, posts sharing routines of taking PDRN supplements before and after procedures are increasing, and this trend has become a distinct phenomenon..

An era has begun where specialized ingredients previously encountered only in hospitals are now taken daily at home.. The industry calls this phenomenon 'internalization of procedures', or 'Inner-Clinic.' Rather than ending with one expensive procedure, it's an approach of taking supplements with the same ingredients alongside the procedure to extend and maintain its effects in daily life..

Post-procedure routines are changing

Skin booster procedures like Rejuran Healer have excellent skin regeneration effects, but they're not a comfortable experience for everyone. The high viscosity of the injection causes pain during the procedure, and embossing (bumpy texture) or bruising can occur immediately after injection..

There's a clear reason why people undergo these procedures despite these inconveniences: they work. That's why it's natural for people to want to maintain the effects of a single procedure as long as possible..

Taking oral PDRN before and after the procedure can reduce the time it takes for the minor inflammation caused by the procedure to subside.. Additionally, the injected component gradually breaks down in the body over time, but by consistently supplying related raw materials through supplements, the regenerative response initiated by the procedure can be sustained longer..

If the injection intensively cares for a specific area, oral intake takes on the role of elevating the condition of the entire skin..

As this routine spreads rapidly through beauty cafes and social media, a perspective viewing procedures and supplements as one package is taking root..

If you'd like to compose an inner clinic routine yourself, I'd recommend also referring to my guide on ['Oral Collagen, Which Product Should You Choose?'?]To expect procedure-level effects from any ingredient, the criteria for choosing products must be different from the start..

Why salmon of all things?

PDRN stands for Polydeoxyribonucleotide.)The name is complex, but explained simply, you can think of it as a finely chopped DNA fragment..

So why salmon among so many organisms?? Salmon DNA has approximately 97% or greater similarity in base sequenceto human DNA..

Due to this high similarity, when DNA fragments extracted from salmon are administered to the human body, the possibility of triggering immune rejection is low.. Specifically, DNA is extracted from salmon milt (Milt), the reproductive cells of male salmon. Milt is an area where DNA is highly concentrated, making it efficient for securing raw materials..

The extracted DNA undergoes heat treatment and chemical purification to achieve over 95% purity.During this process, proteins and fat components that could trigger allergies are removed, allowing it to be safely used as a pharmaceutical or functional food ingredient..

For reference, PDRN is classified according to the length and molecular weight of the DNA fragments:.

Category	PDRN	PN (Polynucleotide))
Molecular Weight	50~1,500 KDa	1,500 KDa or above
Characteristics	Small size, rapid diffusion	Large size, supportive role
Representative Applications	Wound treatment agent, ampoule, oral supplement	Rejuran Healer, intra-articular injection

However, since PDRN is derived from salmon, those with fish allergiesmust absolutely check the ingredient list before consumption.. Although most proteins are removed during the purification process, those with sensitive systems may experience reactions such as itching or hives.. Additionally, pregnant and nursing womenlack sufficient direct safety data, so caution is necessary..

It takes a different approach from collagen

The ingredient that has long served as the main player in the inner beauty market is collagen.. Collagen is a type of protein that serves as a structural framework supporting the skin. As we age, the amount of collagen produced in the body decreases, so the basic logic of collagen supplements is to replenish it from outside..

To use a simple analogy, collagen is like bringing bricks to a building. It's a method of supplying lacking materials from outside. However, the actual amount of collagen that skin can absorb varies greatly depending on the brick's size. This is why low-molecular-weight collagen with a molecular weight of 500 Da or less is gaining attention. You can find detailed information in ['Low-Molecular-Weight Collagen Effects, 500 Da (Dalton) Selection Criteria Comprehensive Guide.'].

However, PDRN's approach is fundamentally different.. Rather than bringing in materials, PDRN signals cells to repair their own structures..

In other words, if collagen physically fills (Filling)) empty spaces in the skin, then PDRN activates a repair (Repair)) system that enables damaged cells to repair themselves. It's about turning on the switch for cellular regeneration..

This difference is why PDRN is evaluated not as a mere trend, but as a paradigm shift in the inner beauty market. We're transitioning from an era of supplying what's lacking from outside to an era of awakening the body's own regenerative capacity..

There's one more point to consider. Newly formed cells that receive regenerative signals are still vulnerable to external stimuli and oxidative stress. To prevent a laboriously repaired structure from collapsing again, a protective barrier is needed.. [Check the protective mechanism in 'Vitamin C and Vitamin E Differences, Why Antioxidants Should Be Taken Together'].

So how exactly does PDRN turn on the cell regeneration switch? I'll address this question in detail in the next installment..

Next Installment Preview!

In this first installment, we examined the background and basic identity of why PDRN suddenly gained attention in the inner beauty market..

In the next second installment, we'll explore how PDRN promotes cellular regeneration through pathways in our body and its scientific mechanism. Names like adenosine receptor and salvage pathway may seem difficult, but I'll explain them as simply as possible..

And in the third installment, we'll organize what to check when actually choosing a PDRN supplement and what precautions to take..

So your skin choices can become wiser, I'll continue in the next installment.!